Siren, L.L.C.

CIK 0002005245 · GREENWICH, CT · Quarter end: 2026-06-30 · Filed on: 2026-08-13 · Open the SEC source

Siren, L.L.C. reported 117 positions worth $4.94B as of June 30, 2026 (13F filed August 13, 2026). Largest holding: SRRK (10.7%).

Portfolio Value (AUM)Total value of the fund's US stock portfolio reported to the SEC.
$4.94B
2026 Q2
Positions
117
Top-10 ConcentrationHow much of the portfolio sits in the 10 largest holdings. High = concentrated bets.
44.6%
Est. Net Flow (Q)
2026 Q2
10 / 117 positions shown
#SymbolCompanyTypeValue% Port.Shares1YYTD
1SRRKScholar Rock Holding CorpSH$526.6M10.66%9,575,013
2KYMRKymera Therapeutics IncSH$336.7M6.81%2,935,830
3ERASErasca IncSH$208.8M4.23%11,397,781
4MANEVeradermics IncSH$203.5M4.12%1,655,374
5TNGXTango Therapeutics IncSH$193.2M3.91%6,179,364
6RVMDRevolution Medicines IncSH$168.6M3.41%900,000
7BCAXBicara Therapeutics IncSH$166.4M3.37%5,602,970
8ARWRArrowhead Pharmaceuticals IncSH$139.8M2.83%1,715,476
9ONCBeOne Medicines AGSH$132.5M2.68%465,000
10EWTXEdgewise Therapeutics IncSH$129.4M2.62%3,184,629

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Read the 2026-Q2 quarterly report · 13F Filing Calendar

Frequently Asked Questions

What stocks does Siren, L.L.C. hold as of Q2 2026?

Siren, L.L.C. reported 117 positions worth $4.94B in its Q2 2026 13F filing. Largest positions: SRRK (10.7%), KYMR (6.8%), ERAS (4.2%), MANE (4.1%) and TNGX (3.9%).

What did Siren, L.L.C. buy in Q2 2026?

No previous quarter is available yet; the comparison appears with the next filing.

What did Siren, L.L.C. sell in Q2 2026?

No previous quarter is available yet.

13F data shows quarter-end positions, is delayed by up to 45 days and covers only long positions in US-listed securities; short positions, most derivatives and non-US assets are not reported.