Opaleye Management Inc.

CIK 0001595855 · BOSTON, MA · Quarter end: 2026-06-30 · Filed on: 2026-08-14 · Open the SEC source

Opaleye Management Inc. reported 58 positions worth $1.10B as of June 30, 2026 (13F filed August 14, 2026). Largest holding: LQDA (17.7%).

Portfolio Value (AUM)Total value of the fund's US stock portfolio reported to the SEC.
$1.10B
2026 Q2
Positions
58
Top-10 ConcentrationHow much of the portfolio sits in the 10 largest holdings. High = concentrated bets.
64.8%
Est. Net Flow (Q)
2026 Q2
10 / 58 positions shown
#SymbolCompanyTypeValue% Port.Shares1YYTD
1LQDALIQUIDIA CORPORATIONSH$195.1M17.67%2,447,500
2ETONETON PHARMACEUTICALS INCSH$103.5M9.38%2,860,000
3HROWHARROW INCSH$101.9M9.23%2,400,000
4IRONDISC MEDICINE INCSH$62.5M5.66%855,000
5URGNUROGEN PHARMA LTDSH$53.0M4.80%1,439,996
603770N101APOGEE THERAPEUTICS INCSH$51.8M4.69%390,000
7MGTXMEIRAGTX HLDGS PLCSH$48.0M4.34%3,550,000
8SLGLSOL-GEL TECHNOLOGIES LTDSH$37.1M3.36%500,000
9RZLTREZOLUTE INCSH$32.8M2.97%6,300,000
10TGTXTG THERAPEUTICS INCSH$29.4M2.66%535,000

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Read the 2026-Q2 quarterly report · 13F Filing Calendar

Frequently Asked Questions

What stocks does Opaleye Management Inc. hold as of Q2 2026?

Opaleye Management Inc. reported 58 positions worth $1.10B in its Q2 2026 13F filing. Largest positions: LQDA (17.7%), ETON (9.4%), HROW (9.2%), IRON (5.7%) and URGN (4.8%).

What did Opaleye Management Inc. buy in Q2 2026?

No previous quarter is available yet; the comparison appears with the next filing.

What did Opaleye Management Inc. sell in Q2 2026?

No previous quarter is available yet.

13F data shows quarter-end positions, is delayed by up to 45 days and covers only long positions in US-listed securities; short positions, most derivatives and non-US assets are not reported.