5AM Venture Management, LLC

CIK 0001799883 · SAN FRANCISCO, CA · Quarter end: 2026-06-30 · Filed on: 2026-08-14 · Open the SEC source

5AM Venture Management, LLC reported 16 positions worth $287.9M as of June 30, 2026 (13F filed August 14, 2026). Largest holding: MPLT (11.8%).

Portfolio Value (AUM)Total value of the fund's US stock portfolio reported to the SEC.
$287.9M
2026 Q2
Positions
16
Top-10 ConcentrationHow much of the portfolio sits in the 10 largest holdings. High = concentrated bets.
85.6%
Est. Net Flow (Q)
2026 Q2
10 / 16 positions shown
#SymbolCompanyTypeValue% Port.Shares1YYTD
1MPLTMAPLIGHT THERAPEUTICS INCSH$34.0M11.83%950,011
2TYRATYRA BIOSCIENCES INCSH$32.9M11.42%1,029,298
3TRDAENTRADA THERAPEUTICS INCSH$29.9M10.37%4,056,379
4PHVSPHARVARIS N VSH$27.6M9.58%797,600
5CAMPCAMP4 THERAPEUTICS CORPSH$25.6M8.91%5,869,091
6ARTVARTIVA BIOTHERAPEUTICS INCSH$22.8M7.93%2,353,304
7TECXTECTONIC THERAPEUTIC INCSH$20.9M7.24%606,660
8ZNTLZENTALIS PHARMACEUTICALS INCSH$19.1M6.65%3,947,913
9CLDXCELLDEX THERAPEUTICS INC NEWSH$18.5M6.43%497,270
10EYPTEYEPOINT INCSH$15.0M5.21%1,050,000

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Read the 2026-Q2 quarterly report · 13F Filing Calendar

Frequently Asked Questions

What stocks does 5AM Venture Management, LLC hold as of Q2 2026?

5AM Venture Management, LLC reported 16 positions worth $287.9M in its Q2 2026 13F filing. Largest positions: MPLT (11.8%), TYRA (11.4%), TRDA (10.4%), PHVS (9.6%) and CAMP (8.9%).

What did 5AM Venture Management, LLC buy in Q2 2026?

No previous quarter is available yet; the comparison appears with the next filing.

What did 5AM Venture Management, LLC sell in Q2 2026?

No previous quarter is available yet.

13F data shows quarter-end positions, is delayed by up to 45 days and covers only long positions in US-listed securities; short positions, most derivatives and non-US assets are not reported.