Two Sigma Investments — IONS Trade History
Quarter-by-quarter changes in the IONIS PHARMACEUTICALS INC position · CUSIP 462222100
Currently held · 9.3 YearsFirst seen: 2017 Q2
| Quarter | Filed | Activity | Shares | Δ Shares | Δ % | Value | % Port. |
|---|---|---|---|---|---|---|---|
| 2026 Q2 | 2026-08-14 | Add | 6,252,342 | 394,713 | +6.7% | $495.7M | 0.36% |
| 2026 Q1 | 2026-05-15 | Add | 5,857,629 | 3,198,983 | +120.3% | $439.8M | 0.35% |
| 2025 Q4 | 2026-02-17 | Add | 2,658,646 | 1,082,703 | +68.7% | $210.3M | 0.30% |
| 2025 Q3 | 2025-11-14 | Reduce | 1,575,943 | -212,424 | -11.9% | $103.1M | 0.15% |
| 2025 Q2 | 2025-08-14 | Add | 1,788,367 | 102,514 | +6.1% | $70.7M | 0.13% |
| 2025 Q1 | 2025-05-15 | Add | 1,685,853 | 764,414 | +83.0% | $50.9M | 0.11% |
| 2024 Q4 | 2025-02-14 | Add | 921,439 | 2,362 | +0.3% | $32.2M | 0.07% |
| 2024 Q3 | 2024-11-14 | Reduce | 919,077 | -109,065 | -10.6% | $36.8M | 0.08% |
| 2024 Q2 | 2024-08-14 | Reduce | 1,028,142 | -55,737 | -5.1% | $49.0M | 0.11% |
| 2024 Q1 | 2024-05-15 | Add | 1,083,879 | 282,431 | +35.2% | $47.0M | 0.11% |
| 2023 Q4 | 2024-02-14 | Add | 801,448 | 325,391 | +68.4% | $40.5M | 0.09% |
| 2023 Q3 | 2023-11-14 | Add | 476,057 | 262,685 | +123.1% | $21.6M | 0.06% |
| 2023 Q2 | 2023-08-14 | Add | 213,372 | 190,292 | +824.5% | $8.8M | 0.02% |
| 2023 Q1 | 2023-05-15 | Reduce | 23,080 | -178,187 | -88.5% | $824.9K | 0.00% |
| 2022 Q4 | 2023-02-14 | Reduce | 201,267 | -91,727 | -31.3% | $7.6M | 0.02% |
| 2022 Q3 | 2022-11-14 | Reduce | 292,994 | -267,037 | -47.7% | $13.0M | 0.04% |
| 2022 Q2 | 2022-08-15 | Reduce | 560,031 | -220,225 | -28.2% | $20.7M | 0.07% |
| 2022 Q1 | 2022-05-16 | Add | 780,256 | 185,371 | +31.2% | $28.9M | 0.09% |
| 2021 Q4 | 2022-02-14 | Add | 594,885 | 280,751 | +89.4% | $18.1M | 0.04% |
| 2021 Q3 | 2021-11-15 | Add | 314,134 | 7,646 | +2.5% | $10.5M | 0.02% |
| 2021 Q2 | 2021-08-16 | Add | 306,488 | 120,768 | +65.0% | $12.2M | 0.03% |
| 2021 Q1 | 2021-05-17 | Add | 185,720 | 18,515 | +11.1% | $8.3M | 0.02% |
| 2020 Q4 | 2021-02-16 | Reduce | 167,205 | -784,931 | -82.4% | $9.5M | 0.03% |
| 2020 Q3 | 2020-11-16 | Add | 952,136 | 341,825 | +56.0% | $45.2M | 0.16% |
| 2020 Q2 | 2020-08-14 | Add | 610,311 | 62,314 | +11.4% | $36.0M | 0.18% |
| 2020 Q1 | 2020-05-15 | Reduce | 547,997 | -93,788 | -14.6% | $25.9M | 0.21% |
| 2019 Q4 | 2020-02-14 | Reduce | 641,785 | -19,220 | -2.9% | $38.8M | 0.12% |
| 2019 Q3 | 2019-11-14 | Reduce | 661,005 | -654,074 | -49.7% | $39.6M | 0.13% |
| 2019 Q2 | 2019-08-14 | Add | 1,315,079 | 528,669 | +67.2% | $84.5M | 0.28% |
| 2019 Q1 | 2019-05-15 | Add | 786,410 | 58,865 | +8.1% | $63.8M | 0.21% |
| 2018 Q4 | 2019-02-14 | Add | 727,545 | 187,876 | +34.8% | $39.3M | 0.15% |
| 2018 Q3 | 2018-11-14 | Add | 539,669 | 389,731 | +259.9% | $27.8M | 0.08% |
| 2018 Q2 | 2018-08-14 | Reduce | 149,938 | -356,031 | -70.4% | $6.2M | 0.02% |
| 2018 Q1 | 2018-05-15 | Add | 505,969 | 335,809 | +197.3% | $22.3M | 0.07% |
| 2017 Q4 | 2018-02-14 | Add | 170,160 | 164,947 | +3164.1% | $8.6M | 0.03% |
| 2017 Q3 | 2017-11-14 | Reduce | 5,213 | -9,690 | -65.0% | $264.0K | 0.00% |
| 2017 Q2 | 2017-08-14 | New | 14,903 | 14,903 | — | $758.0K | 0.00% |
| 2017 Q1 | 2017-05-15 | — | — | — | — | — | — |
| 2016 Q4 | 2017-02-14 | — | — | — | — | — | — |
| 2016 Q3 | 2016-11-14 | — | — | — | — | — | — |
Share counts are split-adjusted. Time held counts consecutive quarters ending with the latest filing; more than ten years shows as ">10 Years".
13F data shows quarter-end positions, is delayed by up to 45 days and covers only long positions in US-listed securities; short positions, most derivatives and non-US assets are not reported.